Nasal drug delivery is one of the more overlooked methods of drug administration. Research is just starting to catch up to the widespread prescribing of nasal sprays by physicians. The nasal sprays most patients will be familiar with are things like decongestants for cold symptom relief and antihistamines for relief of allergy symptoms. However there are many other conditions that can be treated with nasally administered medications. History of Nasal…

A recent study concluded that budesonide in saline nasal rinse results in improvement of chronic rhinosinusitis symptoms. The study was published in the Journal of the American Medical Association Otolaryngology-Head & Neck Surgery and was conducted by researchers at Washington University School of Medicine in St. Louis, Missouri. The researchers wanted to learn what the effect would be of adding budesonide to a large-volume, low-pressure saline sinus irrigation for patients…

Drs. Jonathan Liang and Andrew Lane state in their article on topical drug delivery for chronic rhinosinusitis: “While the introduction of endoscopic sinus surgery revolutionized surgical management and has led to significantly improved patient outcomes, medical therapy remains the foundation of long-term care of chronic rhinosinusitis, particularly in surgically recalcitrant cases. … The goal of topical therapy is to address the inflammation, infection, and mucociliary dysfunction that underlies the disease.”…